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Esomeprazole Magnesium

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stomach acid.

HOME >> Pharmaceuticals API List 1 >> Esomeprazole Magnesium >> Drug Description

DRUG DESCRIPTION
Esomeprazole Magnesium CAS number 161796-78-7

The active ingredient in esomeprazole magnesium Delayed-Release Capsules andFor Delayed-Release Oral Suspension is bis(5 methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-1yl) magnesium trihydrate, a compound that inhibits gastric acid secretion.

Esomeprazole is the S-isomer of omeprazole, which is a mixture of the S- and R- isomers.Its molecular formula is (C17H18N3O3S)2Mg x 3H2O with molecular weight of 767.2 as a trihydrate and 713.1 on an anhydrous basis.The magnesium salt is a white to slightly colored crystalline powder.

It contains 3 moles of water of solvation and is slightly soluble in water.he stability of esomeprazole magnesium is a function of pH; it rapidly degrades in acidic media, but it has acceptable stability under alkaline conditions. At pH 6.8 (buffer), the halflife of the magnesium salt is about 19 hours at 25°C and about 8 hours at 37°C.

Esomeprazole Magnesium relieves heartburn and other symptoms caused by the backflow of stomach acid into the canal to the stomach (the esophagus)—a condition known as gastroesophageal reflux disease. It is also prescribed to heal the damage (erosive esophagitis) that reflux disease can cause.

Prescribed in combination with the antibiotics amoxicillin and clarithromycin, Esomeprazole Magnesium is also used to treat the infection that causes most duodenal ulcers (ulcers occurring just beyond the exit from the stomach).

Like its sister drug omeprazole, Esomeprazole Magnesium works by reducing the production of stomach acid.

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